Rectal Ozone Insufflation Protocol

Rectal Ozone Insufflation Protocol

Micah - The Ozonaut
4 minute read

This rectal ozone insufflation protocol was adapted from The Madrid Declaration by ISCO3

Rectal Ozone Information 

Ozone concentration ranges from 10-50 ug/ml

  • Volume Ranges from 100ml - 750ml
  • It is always recommended to perform this treatment after a bowel movement
  • Rectal ozone may be administered the following ways
  • Ozone Bag - An ozone resistant bag which measures 200, 400, or 750ml

Rectal Ozone Insufflation Protocol (ozone bag method)

Low and Slow Approach 

  • Start patient off on 200ml of 20 gamma ozone for 3 times a week
  • Titrate up 10 gamma each week until patient reaches 40 gamma at 200ml 
  • After 1 month start this process over, but now with 400ml at 3 times a week
  • Practitioner can decide to add additional days of therapy depending on patient tolerance
  • Patient would then stay at 40 gamma/400ml 

Standard Cycling

  • A cycle is the most common rectal ozone insufflation protocol.  The patient is administered ozone therapy on a cycle to allow for the body to adjust.  Select one of the following cycles, whichever is more convenient.
    • Cycle 1: Everyday for three weeks, then one week off.  Continue this cycle until the patient is better, then go into maintenance.  After one month, they may increase to twice a day, based on the discretion of the medical practitioner.
    • Cycle 2: Everyday for five days, then two days off.  Continue this cycle until the patient is better, then go into maintenance.  After one month, they increase to twice a day, based on the discretion of the medical practitioner.
  • Administer 200ml at 20 gamma for the first month.  
  • Administer 200 - 400ml at 20 - 40 gamma thereafter, as the patient is able to tolerate without negative side effects.
  • If the patient is cramping, bloating, or experiencing reasonable discomfort, decrease the dosage and frequency to a tolerable level.

Helpful hints

  • A catheter should only be inserted 3 inches to allow absorption into the portal vein.  If a patient states they feel pressure when they are administering RI, then have them either push the catheter in or pull back on it gently and the ozone will flow freely.  
  • Have the patient keep positive pressure on the bag or syringe when they are administering ozone.  Taking pressure off may cause a back flow of fecal matter in the bag/syringe.  
  • Ozone absorbs into the mucosal lining of the colon extremely quickly.  Thus, there is no need to “trap or hold” the ozone for longer than 20 - 30 seconds.  A bowel movement or flatulence after a treatment is normal and does not indicate an ineffective treatment.

Precautions/Things to lookout for

  • Rectal Ozone is a powerful systemic treatment.  It is recommended that a patient avoid doing both an IV and rectal ozone treatment on the same day.
  • A Herxheimer reaction is possible after a rectal ozone treatment.  This is noticeable when a patient has excessive fatigue, rash, lymph drainage, and/or fever/chills.   
  • If you believe your patient is having a “Herx Reaction”, discontinue their ozone treatment for 4-7 days and allow their system to reset.  Then have them start off on ½ as much gamma and time as previously administered.   Next, titrate back up to the original amount over a timeframe determined by the practitioner.  There are a number of protocols to help prevent a patient from developing a herxheimer reaction.
  • If a patient has mucus stool, then this could be an indicator that they are doing too high of an ozone treatment and would need to be lowered back down to a much smaller gamma of ozone. 

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