Rectal Ozone Insufflation Protocol
This rectal ozone insufflation protocol was adapted from The Madrid Declaration by ISCO3
Rectal Ozone Information
Ozone concentration ranges from 10-50 ug/ml
- Volume Ranges from 100ml - 750ml
- It is always recommended to perform this treatment after a bowel movement
- Rectal ozone may be administered the following ways
- Ozone Bag - An ozone resistant bag which measures 200, 400, or 750ml
Rectal Ozone Insufflation Protocol (ozone bag method)
Low and Slow Approach
- Start patient off on 200ml of 20 gamma ozone for 3 times a week
- Titrate up 10 gamma each week until patient reaches 40 gamma at 200ml
- After 1 month start this process over, but now with 400ml at 3 times a week
- Practitioner can decide to add additional days of therapy depending on patient tolerance
- Patient would then stay at 40 gamma/400ml
- A cycle is the most common rectal ozone insufflation protocol. The patient is administered ozone therapy on a cycle to allow for the body to adjust. Select one of the following cycles, whichever is more convenient.
- Cycle 1: Everyday for three weeks, then one week off. Continue this cycle until the patient is better, then go into maintenance. After one month, they may increase to twice a day, based on the discretion of the medical practitioner.
- Cycle 2: Everyday for five days, then two days off. Continue this cycle until the patient is better, then go into maintenance. After one month, they increase to twice a day, based on the discretion of the medical practitioner.
- Administer 200ml at 20 gamma for the first month.
- Administer 200 - 400ml at 20 - 40 gamma thereafter, as the patient is able to tolerate without negative side effects.
- If the patient is cramping, bloating, or experiencing reasonable discomfort, decrease the dosage and frequency to a tolerable level.
- A catheter should only be inserted 3 inches to allow absorption into the portal vein. If a patient states they feel pressure when they are administering RI, then have them either push the catheter in or pull back on it gently and the ozone will flow freely.
- Have the patient keep positive pressure on the bag or syringe when they are administering ozone. Taking pressure off may cause a back flow of fecal matter in the bag/syringe.
- Ozone absorbs into the mucosal lining of the colon extremely quickly. Thus, there is no need to “trap or hold” the ozone for longer than 20 - 30 seconds. A bowel movement or flatulence after a treatment is normal and does not indicate an ineffective treatment.
Precautions/Things to lookout for
- Rectal Ozone is a powerful systemic treatment. It is recommended that a patient avoid doing both an IV and rectal ozone treatment on the same day.
- A Herxheimer reaction is possible after a rectal ozone treatment. This is noticeable when a patient has excessive fatigue, rash, lymph drainage, and/or fever/chills.
- If you believe your patient is having a “Herx Reaction”, discontinue their ozone treatment for 4-7 days and allow their system to reset. Then have them start off on ½ as much gamma and time as previously administered. Next, titrate back up to the original amount over a timeframe determined by the practitioner. There are a number of protocols to help prevent a patient from developing a herxheimer reaction.
- If a patient has mucus stool, then this could be an indicator that they are doing too high of an ozone treatment and would need to be lowered back down to a much smaller gamma of ozone.